Possible Role Of Thyroid In Epilepsy

Abstract

Thyroid hormone is produced by the thyroid gland. There are two types of thyroid hormone T3( triiodothyronine) & and T4 (thyroxin). They are tyrosine derivatives. They play an important role in the development of CNS and regulate metabolism in our body. Any thyroid hormone deficiency at an early age can lead to neurological dysfunction in adults. These neurological dysfunctions are irreversible. Thyroid hormones also control the development of GAB Anergic neurons. Thyroid hormone inhibitory or excitatory action can cause seizure generation in humans, but there are no significant shreds of evidence about it many hypotheses and studies are available about this. Epilepsy is characterized by seizure episodes, the pathophysiology is associated with mitochondrial dysfunction, oxidative stress, and impairment of GABA neurons. On recent evidence, we can hypothesize that thyroid hormone abnormality can cause epilepsy.